How specific should immunological memory be?
نویسندگان
چکیده
Protection against infection hinges on a close interplay between the innate immune system and the adaptive immune system. Depending on the type and context of a pathogen, the innate system instructs the adaptive immune system to induce an appropriate immune response. Here, we hypothesize that the adaptive immune system stores these instructions by changing from a naive to an appropriate memory phenotype. In a secondary immune reaction, memory lymphocytes adhere to their instructed phenotype. Because cross-reactions with unrelated Ags can be detrimental, such a qualitative form of memory requires a sufficient degree of specificity of the adaptive immune system. For example, lymphocytes instructed to clear a particular pathogen may cause autoimmunity when cross-reacting with ignored self molecules. Alternatively, memory cells may induce an immune response of the wrong mode when cross-reacting with subsequent pathogens. To maximize the likelihood of responding to a wide variety of pathogens, it is also required that the immune system be sufficiently cross-reactive. By means of a probabilistic model, we show that these conflicting requirements are met optimally by a highly specific memory lymphocyte repertoire. This explains why the lymphocyte system that was built on a preserved functional innate immune system has such a high degree of specificity. Our analysis suggests that 1) memory lymphocytes should be more specific than naive lymphocytes and 2) species with small lymphocyte repertoires should be more vulnerable to both infection and autoimmune diseases.
منابع مشابه
P16: The Effect of PTSD on Memory
Post-traumatic stress disorder (PTSD), panic disorder and phobia manifest in ways that are consistent with an uncontrollable state of fear. Impaired memory for elements of the traumatic experience is a core feature of PTSD, and clinical complaints of memory impairment for non-trauma-related stimuli are common. Several studies have documented generalized memory impairment among patients with com...
متن کاملInfluenza virus-specific immunological memory is enhanced by repeated social defeat.
Immunological memory (MEM) development is affected by stress-induced neuroendocrine mediators. Current knowledge about how a behavioral interaction, such as social defeat, alters the development of adaptive immunity, and MEM is incomplete. In this study, the experience of social disruption stress (SDR) prior to a primary influenza viral infection enhanced the frequency and function of the T cel...
متن کاملSurvey of companions of cancer patients about the need and how to express getting incurable cancer
Introduction: Expressing bad news in medicine is one of the most important measures taken by medical staff that should be given to patients in special circumstances that it is necessary to examine the views of companions and patients in this regard. Therefore, the aim of this study was to investigate the necessity and manner of expressing bad news (incurable cancer) from the perspective of canc...
متن کاملDifferences in signaling molecule organization between naive and memory CD4+ T lymphocytes.
The immunological synapse is a highly organized complex formed at the junction between Ag-specific T cells and APCs as a prelude to cell activation. Although its exact role in modulating T cell signaling is unknown, it is commonly believed that the immunological synapse is the site of cross-talk between the T cell and APC (or target). We have examined the synapses formed by naive and memory CD4...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of immunology
دوره 163 2 شماره
صفحات -
تاریخ انتشار 1999